CHALOULT, René, Mémoires politiques. Éditions du Jour, Montréal, 1969. 295 p. $3.00.

Npgrj_nsmb_1227 295..300

Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing tha...

Anticancer Vitamins du Jour—The ABCED's So Far

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. It started 30 years ago with vitamin A: the idea that some cancers might be caused by vitamin deficiencies. Animal experimental models led us to the notion that cancer risk might be ''materially'' reduced by supplementation with beta-carotene, a retinol prec...

Knee dislocations: experience at the Hôpital du Sacré-Coeur de Montréal.

INTRODUCTION Although many options exist for ligament reconstruction in knee dislocations, the optimal treatment remains controversial. Allografts and autografts have both been used to reconstruct the cruciate ligaments. We present the results of reconstruction using artificial ligaments at Hôpital du Sacré-Coeur in Montréal. METHODS We reviewed the treatment of all patients with knee disloca...

Right ventricular strain in pulmonary hypertension: flavor du jour or enduring prognostic index?

Les politiques de l''invisible - Du mythe de l'intégration à la fabrique de l''évidence

A lot of discourses about the so-called « screen civilization » pay little attention to screens. They usually speculate about a supposed cyberspace instead of examining the visible forms of effective communication. This paper looks at what is visible or invisible on computer-supported medias. To do this, it considers both the semiotics of visible signs displayed on the screen and the metasemiot...